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Publications & Research

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  Research Interests   Publications: Journals   Appointments as an Invited Reviewer
  Publications: Books   Research Grants   Professor of Ophthalmology, Anglia Ruskin University




Research Interests

Glaucoma Excavated glaucomatous optic disc Progression of glaucoma
Clinical trials (UK Glaucoma Treatment Study)
Imaging & diagnostic technologies
Epidemiology of POAG & PACG
Shared Care
Cataract Surgery Cataract surgery Clinical trials (MRC study): endothelial effects
Anaesthesia & cataract surgery; IOLs
Epidemiology of Eye Disease Epdiemiology of Eye Disease Global glaucoma; Global refractive errpr
Pakistan: North-West Frontier Pakistan National Eye Survey: Clinical ophthalmology coordinator.
  Bangladesh National Survey Bangladesh National Eye Survey: Clinical ophthalmology coordinator.
  Ittoqqotoormiit, Greenland Greenland: angle-closure glaucoma
  Thailand Glaucoma Survey Thailand: first population-based glaucoma study
  Mount Kilimanjaro Tanzania: epidemic optic neuropathy
Expedition Medicine 2nd British Ascent: 3 highest Arctic peaks Altitude retinopathy; IOP at altitude; Expedition medicine preparation




Publications: Journals

  1. Christopher JL Murray, et al. with R Bourne as co-author. UK health performance: findings of the Global Burden of Disease Study 2010. Lancet 2013: March 5- E pub.

  2. Christopher JL Murray†, Michael J. Richards, John N. Newton, et al. with R Bourne as co-author. United Kingdom Performance on Health: Implications from the Global Burden of Disease Study 2010. Lancet 2013. Submitted fast track.

  3. Bourne R, Gale R. The Ophthalmology Specialty Group and the National Institute for Health Research- the first 6 years. Eye 2013. Accepted for publication.

  4. Gokulan Ratnarajan, Wendy Newsom, Karen French, Jane Kean, Lydia Chang, Mike Parker, David F Garway-Heath, Rupert RA Bourne. The impact of glaucoma referral refinement criteria on referral to, and first-visit discharge rates from, the hospital eye service: the Health Innovation & Education Cluster (HIEC) Glaucoma Pathways project. Ophthalmic Physiol Opt 2013 (accepted. doi: 10.1111/opo.12029).

  5. Lim SS, Vos T, Flaxman AD, et al. with R Bourne as co-author. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2224-60.

  6. Murray CJ, Vos T, Lozano R, et al. with R Bourne as co-author. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2197-223.

  7. Vos T, Flaxman AD, et al, with R Bourne as co-author. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2163-96.

  8. Salomon JA, Vos T, Hogan DR, with R Bourne as co-author. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2129-43.

  9. Gokulan Ratnarajan, Wendy Newsom, Karen French, Jane Kean, Lydia Chang, Mike Parker, David F Garway-Heath, Rupert Richard Alexander Bourne. The effect of changes in referral behaviour following NICE guideline publication on agreement of examination findings between professionals in an established glaucoma referral refinement pathway: The Health Innovation & Education Cluster (HIEC) Glaucoma Pathways project. Br J Ophthalmol 2013;97(2):210-4.

  10. Rupert Bourne, Holly Price, Hugh Taylor, et al. New Systematic Review Methodology for Visual Impairment and Blindness for the 2010 Global Burden of Disease Study. Ophth Epidemiol 2013;20(1):33-9.

  11. The United Kingdom Glaucoma Treatment Study: a multicentre, randomized,placebo-controlled clinical trial. Design and methodology. Ophthalmology 2012 (accepted). Co-author. Manuscript 2012-427R1.

  12. Somner JE, Sii F, Bourne RR, Cross V, Burr JM, Shah P. Moving from PROMs to POEMs for glaucoma care – a qualitative scoping exercise. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5940-7.

  13. McCormick et al. Retinal vessel tortuosity in response to hypobaric hypoxia. High Altitude Medicine and Biology, accepted 2012.

  14. Bourne R, Price H, Stevens G. Global Burden of Visual Impairment and Blindness. Arch Ophthalmol. 2012;130(5):645-647.

  15. Mandalos A, Bourne R, French K, Newsom W, Chang L. Shared care of patients with ocular hypertension in the Community and Hospital Allied Network Glaucoma Evaluation Scheme (CHANGES). Eye (Lond). 2012 Jan 6. doi: 10.1038/eye.2011.350.

  16. Landers J, Martin K, Sarkies N, Bourne R, Watson P. A Twenty-Year Follow-up Study of Trabeculectomy: Risk Factors and Outcomes. Ophthalmology. 2011 Dec 23.

  17. Bourne RR. Eye (Lond). Ethnicity and ocular imaging. 2011 Mar;25(3):297-300. Epub 2010 Dec 17.

  18. Bourne RR, French KA, Chang L, Borman AD, Hingorani M, Newsom WD. Can a community optometrist-based referral refinement scheme reduce false-positive glaucoma hospital referrals without compromising quality of care? The community and hospital allied network glaucoma evaluation scheme (CHANGES). Eye (Lond). 2010 May;24(5):881-7.

  19. Gibbons H, Bourne RR. Extending a nurse practitioner's role to include the undertaking of advanced procedures.. Nurs Times. 2009 Oct 20-26;105(41):24-6.

  20. SP, Jadoon MZ, Dineen B, Bourne RR, Johnson GJ, Gilbert CE, Khan MD. Refractive errors in the adult pakistani population: the national blindness and visual impairment survey. Ophthalmic Epidemiol. 2008 May-Jun;15(3):183-90.

  21. Shah SP, Minto H, Jadoon MZ, Bourne RR, Dineen B, Gilbert CE, Khan MD; Pakistan National Eye Survey Study Group. Prevalence and causes of functional low vision and implications for services: the Pakistan National Blindness and Visual Impairment Survey. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):887-93.

  22. Bourne RR, Foster PJ, Bunce C, Peto T, Hitchings RA, Khaw PT, Seah SK, Garway-Heath DF. The morphology of the optic nerve head in the Singaporean Chinese population (the Tanjong Pagar study): part 2--Biometric and systemic associations. Br J Ophthalmol. 2008 Mar;92(3):310-4.

  23. Bourne RR, Foster PJ, Bunce C, Peto T, Hitchings RA, Khaw PT, Seah SK, Garway-Heath DF. The morphology of the optic nerve head in the Singaporean Chinese population (the Tanjong Pagar study): part 1--Optic nerve head morphology. Br J Ophthalmol. 2008 Mar;92(3):303-9.

  24. Shah SP, Dineen B, Jadoon Z, Bourne R, Khan MA, Johnson GJ, De Stavola B, Gilbert C, Khan MD. Lens opacities in adults in Pakistan: prevalence and risk factors. Ophthalmic Epidemiol. 2007 Nov-Dec;14(6):381-9.

  25. Gilbert CE, Shah SP, Jadoon MZ, Bourne R, Dineen B, Khan MA, Johnson GJ, Khan MD; Pakistan National Eye Survey Study Group. Poverty and blindness in Pakistan: results from the Pakistan national blindness and visual impairment survey. BMJ. 2008 Jan 5;336(7634):29-32. Epub 2007 Dec 17.

  26. Bourne RR, Jahanbakhsh K, Boden C, Zangwill LM, Hoffmann EM, Medeiros FA, Weinreb RN, Sample PA. Reproducibility of visual field end point criteria for standard automated perimetry, full-threshold, and Swedish interactive thresholding algorithm strategies: diagnostic innovations in glaucoma study. Am J Ophthalmol. 2007 Dec;144(6):908-913. Epub 2007 Oct 24.

  27. Uncorrected refractive error and presbyopia: accommodating the unmet need. Br J Ophthalmol. 2007 Jul;91(7):848-50.

  28. Jadoon Z, Shah SP, Bourne R, Dineen B, Khan MA, Gilbert CE, Foster A, Khan MD; Pakistan National Eye Survey Study Group. Cataract prevalence, cataract surgical coverage and barriers to uptake of cataract surgical services in Pakistan: the Pakistan National Blindness and Visual Impairment Survey. Br J Ophthalmol. 2007 Oct;91(10):1269-73.

  29. Dineen B, Bourne RR, Jadoon Z, Shah SP, Khan MA, Foster A, Gilbert CE, Khan MD; Pakistan National Eye Survey Study Group. Causes of blindness and visual impairment in Pakistan. The Pakistan national blindness and visual impairment survey. Br J Ophthalmol. 2007 Aug;91(8):1005-10.

  30. Bourne R, Dineen B, Jadoon Z, Lee PS, Khan A, Johnson GJ, Foster A, Khan D.
    Outcomes of cataract surgery in Pakistan: results from The Pakistan National Blindness and Visual Impairment Survey. Br J Ophthalmol. 2007 Apr;91(4):420-6.

  31. Smith TS, Szetu J, Bourne RR. The prevalence and severity of diabetic retinopathy, associated risk factors and vision loss in patients registered with type 2 diabetes in Luganville, Vanuatu. Br J Ophthalmol. 2007 Apr;91(4):415-9.

  32. Bourne RRA. The Optic Nerve Head in Glaucoma. J Community Eye Health 2006;19:12-13.

  33. Ng D, Zangwill L, Racette L, Bowd C, Pasual J, Bourne R, Boden C, Weinreb R, Sample P. Agreement and Repeatability for Standard Automated Perimetry and Confocal Scanning Laser Ophthalmoscopy in the Diagnostic Innovations in Glaucoma Study. Am J Ophth 2006:142:381-386.

  34. Jadoon MZ, Dineen B, Bourne RRA, Shah SP, Khan A, Johnson GJ, Gilbert CE, Khan MD. Prevalence of blindness and visual impairment in Pakistan: The Pakistan National Blindness and Visual Impairment Survey. Invest Ophthalmol Vis Sci 2006; 47(11):4749-55.

  35. The Eye at Altitude. Daniel Morris, John Somner, Michael Donald, Ian McCormick, Rupert Bourne, Suber Huang, Peter Aspinall, Baljean Dhillon. Advances in Experimental Medicine & Biology. Vol. 588, p249-270.

  36. Hoffmann EM, Boden C, Zangwill LM, Bourne RR, Weinreb RN, Sample PA. Inter-eye comparison of patterns of visual field loss in patients with glaucomatous optic neuropathy. Am J Ophthalmol. 2006 Apr;141(4):703-8.

  37. Hoffmann EM, Medeiros FA, Sample PA, Boden C, Bowd C, Bourne RR, Zangwill LM, Weinreb RN. Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements. Am J Ophthalmol. 2006 Mar;141(3):463-471.

  38. Bowd C, Zangwill LM, Medeiros FA, Tavares IM, Hoffmann EM, Bourne RR, Sample PA, Weinreb RN. Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2889-95.

  39. Robert E MacLaren, Mythili Natkunarajah, Yasmin Riaz, Rupert RA Bourne Marie Restori, Bruce DS Allan. Biometry accuracy with 30+ Diopter Intraocular Lenses: biometry in extreme hyperopia. Am J Ophthalmol. 2007 Jun;143(6):920-931.

  40. Bourne R. Worldwide glaucoma through the looking glass. Br J Ophth. 2006 90:253-254.

  41. Michael H. Goldbaum, Pamela A. Sample, Zuohua Zhang, Kwokleung Chan, Jiucang Hao, Te-Won Lee, Catherine Boden, Christopher Bowd, Rupert Bourne, Linda Zangwill, Terrence Sejnowski, David Spinak, Robert N. Weinreb. Using Unsupervised Learning with Independent Component Analysis to Identify Patterns of Glaucomatous Visual Field Defects. Invest Ophthalmol Vis Sci. 2005 46:3676-3683.

  42. Esther M. Hoffmann, Christopher Bowd, Felipe A. Medeiros, Catherine Boden, Franz H. Grus, Rupert R. Bourne, Linda M. Zangwill, Robert N. Weinreb. Agreement among 3 Optical Imaging Methods for the Assessment of Optic Disc Topography. Ophthalmology 2005 112 (12):2149-56.

  43. R Bourne, B Dineen, Z Jadoon, P Lee, A Khan, G Johnson, A Foster, D Khan, Pakistan National Eye Survey Study Group. The Pakistan National Blindness and Visual Impairment Survey—Research Design, Eye Examination Methodology and Results of the Pilot Study. Ophthalmic Epidemiology 2005 12:321-333.

  44. RRA Bourne, FA Medeiros, C Bowd, K Jahanbakhsh, LM Zangwill, RN Weinreb. Comparability of Retinal Nerve Fiber Layer thickness measurements with Optical Coherence Tomography instruments. Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1280-5.

  45. RRA Bourne, BP Dineen, SM Ali, DM Noorul Huq, GJ Johnson. Correction of Refractive Error in the Adult Population of Bangladesh: Meeting the Unmet Need. Invest Ophthalmol Vis Sci. 2004; 45:410-417.

  46. Bourne RRA, Minassian DC, Dart JKG, Rosen P, Kaushal S, Wingate N. The effect of cataract surgery on the corneal endothelium: phakoemulsification compared with extracapsular cataract surgery. Ophthalmology. 2004 Apr;111(4):679-85.

  47. RRA Bourne, BP Dineen, SM Ali, DM Noorul Huq, GJ Johnson. Prevalence of Refractive Error in Bangladeshi Adults – results of the National Blindness and Low Vision Survey of Bangladesh. Ophthalmology. 2004; 111:1150-1160.

  48. R R A Bourne, B P Dineen, S M Ali, D M N Huq, G J Johnson. The Outcomes of Cataract Surgery in Bangladesh- results from a population-based nationwide survey. Br J Ophthalmol; 87:813-819. 2003.

  49. Bourne RRA, Sukudom P, Foster PJ, Tantisevi V, Jitapunkul S, Lee PS, Johnson GJ, Rojanapongpun P. The prevalence of glaucoma in Thailand: a population-based survey in Rom Klao district, Bangkok. Br J Ophthalmol 2003; 87: 1069-1074.

  50. Dineen B, Bourne RRA, Ali SM, Huq DMN, Johnson GJ. Prevalence and causes of blindness and visual impairment in Bangladeshi adults – results of the National Blindness and Low Vision Survey of Bangladesh. Br J Ophthalmol 2003; 87:820-828.

  51. Bourne RRA, Dineen B, Ali SM, Huq DMN, Johnson GJ. The National Blindness and Low Vision Prevalence Survey of Bangladesh – research design, eye examination methodology and results of the pilot study. Ophthalmic Epidemiology 2002: Vol 9:119-132.

  52. Dineen B, Bourne RRA, Ali SM, Huq DMN, Johnson GJ. Prevalence and causes of blindness and visual impairment in Bangladeshi adults – results of the National Blindness and Low Vision Survey of Bangladesh. Trans. Ophthalmol Soc Bang 2002; 29 (2):101-111.

  53. Bourne RRA, Rosser DA, Sukudom P, Dineen B, Laidlaw DAH, Johnson GJJ, Murdoch IE. Evaluating a new logMAR chart designed to improve visual acuity assessment in population- based surveys. Eye 2003; 17(6): 754-758.

  54. Bourne RRA, Sorensen KE, Klauber A, Foster PJ, Johnson G, Alsbirk PHA. Glaucoma in East Greenlandic Inuit- a population-based survey in Ittoqqortoormiit (Scoresbysund) Acta Ophthalmol Scand. 2001 Oct;79(5):462-7.
    Entry in Health Research in Greenland- 1999 (Innussuk, Arctic Research
    Journal.

  55. Bourne RRA, MacLaren RE, Paralukar M. Excellent visual outcome following perforating gunshot injury to the globe. J R Army Med Corps 2002;148: 144-147.

  56. RRA Bourne, SJ Talks,AB Richards. Treatment of preretinal valsalva haemorrhages with Neodymium:YAG laser. Eye 1999 13:6.

  57. R Bourne, C Karabatsas, HB Hoh, R Finlay. Acute glaucoma associated with iris naevus syndrome. Ophthalmologia 1997, 9:296-299.

  58. HB Hoh, R Bourne, R Baer. Visual recovery following phacoemulsification using topical anaesthesia. J Cataract Refract Surg 1998 Oct; 24(10): 1385-9.

  59. Bourne RR, Ivanov VA, McKenzie SA. Sir John McNee bequest summary of a report on a period of elective study immunzation rates in Moscow preschool children. Trans Med Soc Lond. 1993-94; 110: 119-21.

  60. Bourne RRA, MacLaren RE. Intracranial plasmacytoma masquerading as Gradenigo's Syndrome. Br J Ophthalmol 1998; 82:456.

  61. Bourne RRA, Dolin PJ, Mtanda AT, Plant GT, Mohamed AA. Epidemic optic neuropathy in primary school children in Dar es Salaam, Tanzania. Br J Ophthalmol 1998; 82: 232-234.

  62. Bourne RRA, Greenwald S. The application of histomorphometric image analysis to the quantification of aortic scleroprotein and smooth muscle content. J Pathology 1993; 169: 163a.

  63. Bourne RRA, Ivanov V, McKenzie S. Vaccination rates in Moscovite children. Lancet 1994; 344: 1366.



Appointments as an Invited Reviewer

I have been an invited reviewer for the following journals:
  • Acta Scandinavica Ophthalmologica
  • Ophthalmic Epidemiology
  • Investigative Ophthalmology and Visual Science
  • Eye
  • American Journal of Ophthalmology
  • Public Library of Science (Academic Editor)
  • British Journal of Ophthalmology


Publications: Books

  1. Scanning Laser Imaging in Atlas of Glaucoma, 2nd Edition. Choplin, N.T. & Lundy, D.C. Eds. Authors: C Bowd, LM, Zangwill, RRA Bourne, RN Weinreb. 2006.

  2. The Eye at Altitude. Daniel Morris, John Somner, Michael Donald, Ian McCormick, Rupert Bourne, Suber Huang, Peter Aspinall, Baljean Dhillon. Advances in Experimental Medicine & Biology. Vol. 588, p249-270.

  3. Wolff's Anatomy of the Eye and Orbit. AJ Bron, RC Tripathi, BJ Tripathi. Contributed a section on racial differences in optic disc morphology.

  4. Royal Geographical Society Expedition Medicine 2002, 2nd Edition. Profile Books, London. Contributed the ophthalmology perspective.

  5. World Glaucoma Association: Intraocular Pressure - Consensus Series.

  6. Kugler Publications 2007. Contributed to a section on the 'Epidemiology of Intraocular Pressure'.


Research Grants

Table 1: Glaucoma

GLAUCOMA Studies
(CI/PI: Chief/Principal Investigator)
Grant Support
Imaging of the Optic Nerve Head & Nerve Fibre Layer 1. Studies involving OCT & HRT & SLP: diagnostic precision; backwards compatability Heidelberg Engineering, TFC Frost
  2. UK Glaucoma Treatment Study: site PI (NIHR 5739) Pfizer
  3. Comparative study of new imaging technologies for the diagnosis of glaucoma: the GATE study: site PI NIHR HTA
  4. MD thesis. Optic nerve morphology in East Asian populations. International Glaucoma Association
Angle Closure Glaucoma 1. Investigating Management of Angle Closure and Treatment study: IMPACT: CI (NIHR 8955) Allergan
NIHR-FSF
  2. Effectiveness in Angle closure Glaucoma of Lens Extraction: EAGLE: site PI MRC funded
Glaucoma Care Pathways in UK 1. Health Innovation Education Cluster project: Glaucoma Referral refinement pathways in the UK UK govt: HIEC programme (ARU & UCL collaboration)
  2. The Community & Glaucoma Allied Network Glaucoma Evaluation Scheme: CHANGES: CI Allergan: Diagnostic Innovations Award 2007
Functional aspects of Glaucoma 1. Precision Tasks in patients with Glaucoma: collaboration with ARU NIHR-FSF funding
Circadian IOP 1. 24-hour IOP in newly diagnosed glaucoma: collaboration with Papworth sleep laboratory NIHR-FSF funding & Dora Brown bequest
Electronic Patient Records for Glaucoma 1. Electronic Records – User Requirements, Usability and Workflow Impact: CI (NIHR:12694) UK Govt Knowledge Transfer Partnership grant & Medisoft Ltd
  2. Patient Outcome & Experience Measures: collaborating investigator  
  3. The National Ophthalmology Database: Glaucoma Project International Glaucoma Association


Table 2: Ophthalmic Epidemiology (including Epidemiology of Glaucoma)

OPHTHALMIC EPIDEMIOLOGY Studies
(CI/PI: Chief/Principal Investigator)
Grant Support
Global Burden of Disease Study 1. Contribution of Vision Loss to Global Burden of Disease: Lead for Vision Loss Expert Gp Bill & Melinda Gates Foundation. Fight for Sight UK
  2. Maintenance of global database on Vision Loss & Visualisations Project Brien Holden Vision Institute
National studies of eye disease 1. Pakistan National Eye Survey: CI Sightsavers International, WHO. Fred Hollows Foundation, Christen Blinden Mission
  2. Bangladesh National Eye Survey: CI Sightsavers International. British Council for Prevention Blindness
  3. National Eye Survey of Trinidad & Tobago. Co-CI. Govt Trinidad & Tobago.
Fight for Sight UK.
  4. Prevalence of Glaucoma in Thailand. CI IGA
  5. Angle closure in Greenland. CI Gino Watkins Memorial Fund. TFC Frost. Grosserer Christian Andersen og hustru Ingeborg Ovidia Signe Andersen, født Schmidts Legat.


Table 3: Other Research Areas

OTHER RESEARCH AREAS Studies
(CI/PI: Chief/Principal Investigator)
Grant Support
Expedition Medicine 1. Oxford Handbook of Expedition Medicine. Contributing author voluntary
High Altitude Ophthalmology 1. Altitude retinopathy voluntary
National studies of eye disease 1. Pakistan National Eye Survey: CI Sightsavers International, WHO. Fred Hollows Foundation, Christen Blinden Mission
  2. Bangladesh National Eye Survey: CI Sightsavers International. British Council for Prevention Blindness
  3. National Eye Survey of Trinidad & Tobago. Co-CI. Govt Trinidad & Tobago.
Fight for Sight UK.
  4. Prevalence of Glaucoma in Thailand. CI IGA
  5. Angle closure in Greenland. CI Gino Watkins Memorial Fund. TFC Frost. Grosserer Christian Andersen og hustru Ingeborg Ovidia Signe Andersen, født Schmidts Legat.




Professor of Ophthalmology, Anglia Ruskin University

Appointed in July 2007 to the post of Professor of Ophthalmology, I have a role in developing new avenues of research and enhancing the training within the School of Optometry which is part of the Faculty of Science and Technology at Anglia Ruskin University.

Arrangements have been made for optometry students to train in clinical practice at the Ophthalmology Department of Hinchingbrooke Hospital, where medical students also undergo ophthalmology training. Research collaborations already exist between the Huntingdon Glaucoma Diagnostic & Research Centre and Moorfields Eye Hospital, and it is envisaged that further collaborations will ensue with Anglia Ruskin.